Journal
REDOX BIOLOGY
Volume 12, Issue -, Pages 18-34Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2017.01.007
Keywords
Neovascularization; Angiogenesis; VEGF; Atherosclerosis; Hypercholesterolemia
Categories
Funding
- Inserm (Institut National de la Sante et de la Recherche Medicale)
- ANR-Carina [ANR-12-BSV1-0016-01]
- IdEx Emergence call-PALMA
- Universite Paul Sabatier Toulouse-3
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV1-0016] Funding Source: Agence Nationale de la Recherche (ANR)
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Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries characterized by a local accumulation of cholesterol and non-resolving inflammation. Atherothrombotic complications are the leading cause of disability and mortality in western countries. Neovascularization in atherosclerotic lesions plays a major role in plaque growth and instability. The angiogenic process is mediated by classical angiogenic factors and by additional factors specific to atherosclerotic angiogenesis. In addition to its role in plaque progression, neovascularization may take part in plaque destabilization and thromboembolic events. Anti-angiogenic agents are effective to reduce atherosclerosis progression in various animal models. However, clinical trials with antiangiogenic drugs, mainly anti-VEGF/VEGFR, used in anti-cancer therapy show cardiovascular adverse effects, and require additional investigations.
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