Journal
REDOX BIOLOGY
Volume 12, Issue -, Pages 946-955Publisher
ELSEVIER
DOI: 10.1016/j.redox.2017.04.030
Keywords
Shotgun lipidomics; Oxidative stress; Lipid peroxidation; Oxidized fatty acids; 4-hydroxyalkenal species; Plasmalogen
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Funding
- National Institute of General Medical Sciences Grant [R01 GM105724]
- Science and Technology Planning Project of Zhejiang Province [2015C37025]
- National Natural Science Foundation of China [81373633]
- National Basic Research Program 973 of China [2014CB543001]
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Multi-dimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) has made profound advances for comprehensive analysis of cellular lipids. It represents one of the most powerful tools in analyzing lipids directly from lipid extracts of biological samples. It enables the analysis of nearly 50 lipid classes and thousands of individual lipid species with high accuracy/precision. The redox imbalance causes oxidative stress, resulting in lipid peroxidation, and alterations in lipid metabolism and homeostasis. Some lipid classes such as oxidized fatty acids, 4-hydroxyalkenal species, and plasmalogen are sensitive to oxidative stress or generated corresponding to redox imbalance. Therefore, accurate assessment of these lipid classes can provide not only the redox states, but also molecular insights into the pathogenesis of diseases. This review focuses on the advances of MDMS-SL in analysis of these lipid classes and molecular species, and summarizes their recent representative applications in biomedical/biological research. We believe that MDMS-SL can make great contributions to redox biology through substantiating the aberrant lipid metabolism, signaling, trafficking, and homeostasis under oxidative stress-related condition.
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