Journal
REDOX BIOLOGY
Volume 11, Issue -, Pages 606-612Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2017.01.009
Keywords
Parkinson's disease; Induced dopaminergic neuron; Induced neuron; Induced pluripotent stem cell; Transcription factor
Categories
Funding
- Department of Veterans Affairs Merit Award [I01BX002452]
- NYSTEM [C028129, C029556, C026714]
- SUNY REACH, National Program of Basic Research Fund of China [2010CB945200, 2011CB504104]
- National Natural Science Fund [81430022, 81371407, 91332107]
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Motor symptoms that define Parkinson's disease (PD) are caused by the selective loss of nigral dopaminergic (DA) neurons. Cell replacement therapy for PD has been focused on midbrain DA neurons derived from human fetal mesencephalic tissue, human embryonic stem cells (hESC) or human induced pluripotent stem cells (iPSC). Recent development in the direct conversion of human fibroblasts to induced dopaminergic (iDA) neurons offers new opportunities for transplantation study and disease modeling in PD. The iDA neurons are generated directly from human fibroblasts in a short period of time, bypassing lengthy differentiation process from human pluripotent stem cells and the concern for potentially tumorigenic mitotic cells. They exhibit functional dopaminergic neurotransmission and relieve locomotor symptoms in animal models of Parkinson's disease. In this review, we will discuss this recent development and its implications to Parkinson's disease research and therapy.
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