Journal
EUROPEAN RESPIRATORY JOURNAL
Volume 45, Issue 4, Pages 1150-1162Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00141514
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Funding
- Lung Foundation Netherlands (Amersfoot, the Netherlands)
- Grifols (Frankfurt am Main, Germany)
- Galapagos NV (Mechelen, Belgium)
- Roy J. Carver Charitable Trust (Muscatine IA, USA)
- Deutsche Forschungsgemeinschaft (Bonn, Germany) [Ba 1641/12]
- Bundesministerium fur Forschung (Bonn) [01Gl1001, 01 GM111 OB, 01 Kl1 01 OC]
- [NIH HL-51670]
- [HL-091842]
- [HL-118000]
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The airway epithelium is now considered to be central to the orchestration of pulmonary inflammatory and immune responses, and is also key to tissue remodelling. It acts as the first barrier in the defence against a wide range of inhaled challenges, and is critically involved in the regulation of both innate and adaptive immune responses to these challenges. Recent progress in our understanding of the developmental regulation of this tissue, the differentiation pathways, recognition of pathogens and antimicrobial responses is now exploited to help understand how epithelial cell function and dysfunction contributes to the pathogenesis of a variety of inflammatory lung diseases. Herein, advances in our knowledge of the biology of airway epithelium, as well as its role and (dys)function in asthma, chronic obstructive pulmonary fibrosis and cystic fibrosis will be discussed.
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