Journal
REDOX BIOLOGY
Volume 13, Issue -, Pages 331-335Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2017.05.022
Keywords
-
Categories
Funding
- American Cancer Society [122437-RP-12-090-01-COUN]
- Armstrong Family Foundation
- Cindy Rosencrans Foundation
- Department of Defense Breast Cancer Research Program [W81XWH-12-1-0464]
- Emerson Collective Cancer Research Fund
Ask authors/readers for more resources
Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O-2 availability, electron transport becomes less efficient, leading to increased generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available