Journal
BIONANOSCIENCE
Volume 6, Issue 4, Pages 352-354Publisher
SPRINGER
DOI: 10.1007/s12668-016-0232-y
Keywords
Nuclear magnetic resonance; Fluvastatin; Micelles; Molecular complex
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Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.
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