Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 4, Issue 7, Pages 1350-1353Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qo00167c
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Funding
- NSFC [21232005, 21375113]
- National Basic Research Program of China [2013CB910700]
- Fundamental Research Funds for the Central Universities [20720160030]
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Pyrrolo[1,2-a]indole and organosulfone are common structural motifs found in many pharmaceuticals. An efficient approach for the synthesis of 2-sulfonated 9H-pyrrolo[1,2-a]indoles via a NaI-catalyzed sulfonyl-radical-involved cascade cyclization-isomerization process is described. By using sodium iodide as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant, various N-propargyl-substituted indoles and sulfonyl hydrazides are tolerated in this transformation, affording the corresponding products in moderate to good yields.
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