Palladium catalyzed C(sp3)-H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

It still remains a major challenge to apply free primary amino groups as the directing group for aliphatic C-H functionalization. In this article, we used the protonation strategy to control the binding ability of primary amines and realized free amino group directed inert aliphatic C-H acetoxylation in good chemo- and regio-selectivity. This methodology provided a straightforward approach from primary amines to gamma-amino alcohols.