4.7 Article

Aerobic oxidative decyanation-amidation of arylacetonitriles with urea as a nitrogen source

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 4, Issue 3, Pages 331-334

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6qo00635c

Keywords

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Funding

  1. National Natural Science Foundation of China [21202049]
  2. Recruitment Program of Global Experts (1000 Talents Plan)
  3. Natural Science Foundation of Fujian Province [2016J01064]
  4. Fujian Hundred Talents Plan and Program of Innovative Research Team of Huaqiao University [Z14X0047]
  5. Promotive Program for Young and Middle-aged Teacher in Science and Technology Research of Huaqiao University

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An iron-catalyzed aerobic oxidative amidation reaction of the inert C-CN bond of aryl acetonitriles to afford aryl amides has been developed. Urea is used as an efficient and convenient nitrogen source. This reaction provides practical access toward amide synthesis.

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