Journal
OPEN CHEMISTRY
Volume 15, Issue 1, Pages 219-224Publisher
SCIENDO
DOI: 10.1515/chem-2017-0025
Keywords
Terpenoids; antimicrobial; red algae; Red Sea
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Purification of the organic extract of Laurencia obtusa Lamouroux by column chromatography and preparative thin layer chromatography provided four new compounds: a eudesmane-type sesquiterpenoid [eudesma4(15), 11-diene-5,7-diol (1)], a cuparane-type sesquiterpenoid [10-hydroxycuparaldehyde (2)], and two nor-cuparanes [3-hydroxy-15-nor-cuparan-10 beta-ol (3) and 2-bromo-3hydroxy- 15-nor-cuparan-10 beta-ol (4)]. Structural identification was made possible by comparison of spectral data with those reported in the literature. Compounds 3 and 4 are significant as nor-cuparanes are rarely isolated from marine environment. 1 showed moderate anticandidal activity, whereas 2 exhibited reasonable antibacterial activity against multidrug-resistant bacteria (especially Gram-positive). All the compounds are nontoxic to Artemia salina.
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