Journal
ONCOIMMUNOLOGY
Volume 6, Issue 9, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2017.1339857
Keywords
abscopal effect; cGAS; immune checkpoint blockers; nucleic acids sensing; radiotherapy; STING; type I interferon
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Funding
- NIH [R01 CA201246, S10 RR027619]
- Breast Cancer Research Foundation [BCRF-16-054]
- Chemotherapy Foundation
- DOD BCRP [W81XWH-13-1-0012]
- Anna-Maria and Stephen Kellen Foundation
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The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA. TREX1 upregulation by radiation dose per fraction beyond a threshold of 10-12Gy results in poor synergy with immune checkpoint blockers.
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