Journal
NATIONAL SCIENCE REVIEW
Volume 5, Issue 2, Pages 269-286Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nsr/nwx062
Keywords
tumor microenvironment; cancer targeting; nanomedicine; theranostics
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The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards.
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