Journal
MOLECULAR METABOLISM
Volume 6, Issue 11, Pages 1443-1453Publisher
ELSEVIER
DOI: 10.1016/j.molmet.2017.08.008
Keywords
S6K1; Exercise; Glycemic control; Metabolic phenotyping; Reactive oxidative species
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Funding
- Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia (MIWF NRW)
- German Federal Ministry of Health (BMG)
- Deutsche Forschungsgemeinschaft [SFB1116]
- German Academic Exchange Service (DAAD)
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Objective: Ribosomal protein S6 Kinase-1 (S6K1) has been linked to resistance exercise-mediated improvements in glycemia. We hypothesized that S6K1 may also play a role in regulating glycemic control in response to endurance exercise training. Methods: S6k1-knockout (S6K1K0) and WT mice on a 60 cal% high-fat diet were trained for 4 weeks on treadmills, metabolically phenotyped, and compared to sedentary controls. Results: WT mice showed improved glucose tolerance after training. In contrast, S6K1K0 mice displayed equally high glucose tolerance already in the sedentary state with no further improvement after training. Similarly, training decreased mitochondrial ROS production in skeletal muscle of WT mice, whereas ROS levels were already low in the sedentary S6K1K0 mice with no further decrease after training. Nevertheless, trained S6K1K0 mice displayed an increased running capacity compared to trained WT mice, as well as substantially reduced triglyceride contents in liver and skeletal muscle. The improvements in glucose handling and running endurance in S6K1K0 mice were associated with markedly increased ketogenesis and a higher respiratory exchange ratio. Conclusions: In high-fat fed mice, loss of S6K1 mimics endurance exercise training by reducing mitochondria! ROS production and upregulating oxidative utilization of ketone bodies. Pharmacological targeting of S6K1 may improve the outcome of exercise-based interventions in obesity and diabetes. (C)2017 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license.
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