4.7 Article

Dual-Phase Dual-Energy CT in Patients Treated with Erlotinib for Advanced Non-Small Cell Lung Cancer: Possible Benefits of Iodine Quantification in Response Assessment

Journal

EUROPEAN RADIOLOGY
Volume 26, Issue 8, Pages 2828-2836

Publisher

SPRINGER
DOI: 10.1007/s00330-015-4092-6

Keywords

Dual-energy CT; Iodine contrast medium; Lung cancer; Targeted molecular therapy; Therapy response

Funding

  1. Charles University Research Fund [P36]
  2. Ministry of Health, Czech Republic - the project of conceptual development of research organization (Faculty Hospital in Pilsen - FNPI) [00669806]

Ask authors/readers for more resources

To investigate the relationship of dual-phase dual-energy CT (DE-CT) and tumour size in the evaluation of the response to anti-EGFR therapy in patients with advanced non-small cell lung cancer (NSCLC). Dual-phase DE-CT was performed in 31 patients with NSCLC before the onset of anti-EGFR (erlotinib) therapy and as follow-up (mean 8 weeks). Iodine uptake (IU; mg/mL) was quantified using prototype software in arterial and venous phases; arterial enhancement fraction (AEF) was calculated. The change of IU before and after therapy onset was compared with anatomical evaluation in maximal transverse diameter and volume (responders vs. non-responders). A significant decrease of IU in venous phase was proved in responders according to all anatomical parameters (p=0.002-0.016). In groups of non-responders, a significant change of IU was not proved with variable trends of development. The most significant change was observed using the anatomical parameter of volume (cut-off 73 %). A significant difference of percentage change in AEF was proved between responding and non-responders (p=0.019-0.043). Dual-phase DE-CT with iodine uptake quantification is a feasible method with potential benefit in advanced assessment of anti-EGFR therapy response. We demonstrated a decrease in vascularization in the responding primary tumours and non-significant variable development of vascularization in non-responding tumours. aEuro cent Dual-phase DE-CT is feasible for vascularization assessment of NSCLC with anti-EGFR therapy. aEuro cent There was a significant decrease of iodine uptake in responding tumours. aEuro cent There was a non-significant and variable development in non-responding tumours. aEuro cent There was significant difference of AEF percentage change between responders and non-responders.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available