Journal
EUROPEAN RESPIRATORY REVIEW
Volume 25, Issue 142, Pages 472-486Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/16000617.0063-2016
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Funding
- European Respiratory Society [STRTF 2015-9508]
- NHS Research Scotland Career Research Fellowship
- CareFusion
- European Respiratory Society Fellowship [RESPIRE2 - 2015-7160]
- Chief Scientist Office [ETM/285] Funding Source: researchfish
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Malignant pleural mesothelioma is an aggressive malignancy of the pleural surface, predominantly caused by prior asbestos exposure. There is a global epidemic of malignant pleural mesothelioma underway, and incidence rates are predicted to peak in the next few years. This article summarises the epidemiology and pathogenesis of malignant pleural mesothelioma, before describing some key factors in the patient experience and outlining common symptoms. Diagnostic approaches are reviewed, including imaging techniques and the role of various biomarkers. Treatment options are summarised, including the importance of palliative care and methods of controlling pleural effusions. The evidence for chemotherapy, radiotherapy and surgery is reviewed, both in the palliative setting and in the context of trimodality treatment. An algorithm for managing malignant pleural effusion in malignant pleural mesothelioma patients is presented. Finally new treatment developments and novel therapeutic approaches are summarised.
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