Journal
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
Volume 1, Issue 4, Pages 236-242Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2016.09.006
Keywords
Synthetic biology; Polyhydroxyalkanoates; 973; Bioprocesses; Pathways
Categories
Funding
- State Basic Science Foundation 973 [2012CB725201]
- National Natural Science Foundation of China [31430003, 31270146]
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Microbial polyhydroxyalkanoates (PHA) have been produced as bioplastics for various purposes. Under the support of China National Basic Research 973 Project, we developed synthetic biology methods to diversify the PHA structures into homo-, random, block polymers with improved properties to better meet various application requirements. At the same time, various pathways were assembled to produce various PHA from glucose as a simple carbon source. At the end, Halomonas bacteria were reconstructed to produce PHA in changing morphology for low cost production under unsterile and continuous conditions. The synthetic biology will advance the PHA into a bio-and material industry. (c) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co.
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