Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
Volume 5, Issue 4, Pages 1008-+Publisher
ELSEVIER
DOI: 10.1016/j.jaip.2016.10.020
Keywords
Inner-city asthma; Childhood asthma; Mouse sensitization; Mouse allergen; Indoor allergens
Categories
Funding
- National Institutes of Health [U01 Al 083238, K24 AI 106822, K24 AI114769 R01 ES023447, P50ES015903, P01 ES018176]
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BACKGROUND: Mouse sensitization and exposure are associated with uncontrolled asthma, but whether they are associated with asthma severity, an intrinsic disease characteristic and long-term outcome predictor, is unclear. OBJECTIVE: To examine relationships between mouse sensitization and/or exposure and asthma severity in urban children. METHODS: A total of 645 children (5-17 years) with uncontrolled asthma underwent mouse sensitization evaluation. Sensitized children had mouse allergen measured in bedroom dust. Relationships between mouse sensitization, allergen levels, and asthma severity measures (treatment step and Composite Asthma Severity Index [CASI]) were examined using regression models adjusted for age, sex, atopy, study site, race, ethnicity, and insurance. RESULTS: The study population was predominantly minority (69.6% black, 20.8% Hispanic), low income (61.8%), and mouse sensitized (54.4%). Mean +/- SD treatment step was 3.2 +/- 1.6, equivalent to medium-dose inhaled corticosteroid. Mean +/- SD CASI was 6.5 +/- 3.4, reflecting moderate persistent asthma. Mouse sensitization was associated with higher treatment step (3.5 vs 2.9, mouse-sensitized vs nonsensitized, P < .001), independent of potential confounders (beta [95% CI], 0.36 [0.07-0.64]; P = .01). Mouse sensitization was associated independently with CASI (beta [95% CI], 0.82 [0.16-1.47]; P[. 02). Among mouse-sensitized participants, higher bedroom floor and bed Mus m 1 were independently associated with treatment step (beta [95% CI], 0.26 [0.09-0.43]; P = .002 and beta [95% CI], 0.22 [0.01-0.43]; P = .002, respectively. Higher bedroom floor Mus m 1 was independently associated with CASI (beta [95% CI], 0.43 [0.05-0.81]; P = .03). CONCLUSIONS: Mouse sensitization and exposure are associated with asthma severity, among low-income, minority children. Further studies are needed to determine whether reducing allergen exposure among mouse-sensitized patients with asthma can reduce severity, ultimately altering childhood asthma natural history. (C) 2016 American Academy of Allergy, Asthma & Immunology
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