Journal
JOURNAL OF MEDICAL IMAGING
Volume 3, Issue 3, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JMI.3.3.036001
Keywords
hyperpolarization; magnetic resonance imaging; silicon nanoparticles; molecular imaging
Funding
- MD Anderson Cancer Center Odyssey Postdoctoral Fellowship
- NCI [R25T CA057730/CA016672, U54 CA151668, P50 CA083639, R21 CA185536]
- DoD [PC131680]
- MDACC Institutional Research Grants
- MDACC Institutional Startup
- Leukemia and Brain SPORE Developmental Research Awards
- Gulf Coast Consortium
- Blanton-Davis Ovarian Cancer Research Program Grant
- CPRIT [RP150701]
- NCI Cancer Center Support Grant [CA016672]
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Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization, which increases magnetic resonance imaging signals by several orders-of-magnitude through enhanced nuclear spin alignment, has recently been developed to allow silicon particles to function as contrast agents for in vivo magnetic resonance imaging. The enhanced spin polarization of silicon lasts significantly longer than other hyperpolarized agents (tens of minutes, whereas <1 min for other species at room temperature), allowing a wide range of potential applications. We report our recent characterizations of hyperpolarized silicon particles, with the ultimate goal of targeted, noninvasive, and nonradioactive molecular imaging of various cancer systems. A variety of particle sizes (20 nm to 2 mu m) were found to have hyperpolarized relaxation times ranging from similar to 0 to 50 min. The addition of various functional groups to the particle surface had no effect on the hyperpolarization buildup or decay rates and allowed in vivo imaging over long time scales. Additional in vivo studies examined a variety of particle administration routes in mice, including intraperitoneal injection, rectal enema, and oral gavage. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
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