Related references
Note: Only part of the references are listed.Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function
Carla Garza-Lombo et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2016)
Compromised autophagy and neurodegenerative diseases
Fiona M. Menzies et al.
NATURE REVIEWS NEUROSCIENCE (2015)
mTOR IN BRAIN PHYSIOLOGY AND PATHOLOGIES
Joel Bockaert et al.
PHYSIOLOGICAL REVIEWS (2015)
mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1
Sebastiano Sciarretta et al.
CELL REPORTS (2015)
Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease
Sebastiano Sciarretta et al.
CIRCULATION RESEARCH (2014)
mTOR controls kidney epithelia in health and disease
Florian Grahammer et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2014)
Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease
J. Romani-Aumedes et al.
CELL DEATH & DISEASE (2014)
Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation
B. I. Perez-Revuelta et al.
CELL DEATH & DISEASE (2014)
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
Antonella Caccamo et al.
AGING CELL (2013)
Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage
Mirko Voelkers et al.
CIRCULATION (2013)
Regulation of mTORC1 and its impact on gene expression at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2013)
Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson's Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy
Tian-Fang Jiang et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)
Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor
Sajjad Hussain et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Autophagy Modulation for Alzheimer's Disease Therapy
Xi-Chen Zhu et al.
MOLECULAR NEUROBIOLOGY (2013)
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
Alejo Efeyan et al.
NATURE (2013)
mTOR is a key modulator of ageing and age-related disease
Simon C. Johnson et al.
NATURE (2013)
Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1
Mirko Voelkers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
Mickael Decressac et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia Pathophysiological Implications in Obesity and Metabolic Syndrome
Sebastiano Sciarretta et al.
CIRCULATION (2012)
Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway
Anindita Das et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)
Conditional Expression of Parkinson's Disease-Related Mutant α-Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1
Xian Lin et al.
JOURNAL OF NEUROSCIENCE (2012)
Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?
Zhiyou Cai et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2012)
Aβ Toxicity in Alzheimer's Disease
Virve Cavallucci et al.
MOLECULAR NEUROBIOLOGY (2012)
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
Xiaoqing Gan et al.
NATURE CELL BIOLOGY (2012)
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia
Srinivasa Subramaniam et al.
NATURE NEUROSCIENCE (2012)
Activation of mTORC2 by Association with the Ribosome
Vittoria Zinzalla et al.
CELL (2011)
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
Timothy R. Peterson et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
Jessica L. Yecies et al.
CELL METABOLISM (2011)
Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion
Peiyong Zhai et al.
CIRCULATION RESEARCH (2011)
Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
Yanyun Gu et al.
DIABETES (2011)
A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway
Yuan Tian et al.
FASEB JOURNAL (2011)
Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1
Andrew Philp et al.
JOURNAL OF APPLIED PHYSIOLOGY (2011)
A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1 ACTIVATION OF AKT VIA MTORC2
Hitoshi Murata et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile
Beatrice T. Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload
Zhongbing Lu et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
Larissa S. Carnevalli et al.
DEVELOPMENTAL CELL (2010)
Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
Lynda Elghazi et al.
DIABETES (2010)
Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells
Boris Shor et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau EFFECTS ON COGNITIVE IMPAIRMENTS
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death
Kyou-Chan Choi et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Rapamycin Protects against Neuron Death in In Vitro and In Vivo Models of Parkinson's Disease
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Shomit Sengupta et al.
NATURE (2010)
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
T. Sato et al.
ONCOGENE (2010)
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
Shijie Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
Theodoros Kantidakis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
Ker Yu et al.
CANCER RESEARCH (2009)
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Paul Nicklin et al.
CELL (2009)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson et al.
CELL (2009)
TRPC1 Channels Are Critical for Hypertrophic Signaling in the Heart
Malini Seth et al.
CIRCULATION RESEARCH (2009)
An Emerging Role of mTOR in Lipid Biosynthesis
Mathieu Laplante et al.
CURRENT BIOLOGY (2009)
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
Carson C. Thoreen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
Hui H. Zhang et al.
PLOS ONE (2009)
Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
Emanuela Santini et al.
SCIENCE SIGNALING (2009)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
BIOCHEMICAL JOURNAL (2008)
Role of mTOR in physiology and pathology of the nervous system
Lukasz Swiech et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)
Integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
Katherine Stemke-Hale et al.
CANCER RESEARCH (2008)
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Pazit Polak et al.
CELL METABOLISM (2008)
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
C. Florian Bentzinger et al.
CELL METABOLISM (2008)
Selective versus total insulin resistance: A pathogenic paradox
Michael S. Brown et al.
CELL METABOLISM (2008)
mTOR inhibition by rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
Merav Fraenkel et al.
DIABETES (2008)
Role of TSC-mTOR pathway in diabetic nephropathy
Ken Inoki
DIABETES RESEARCH AND CLINICAL PRACTICE (2008)
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Tsuneo Ikenoue et al.
EMBO JOURNAL (2008)
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
Yuzuru Imai et al.
EMBO JOURNAL (2008)
Biphasic response of pancreatic β-cell mass to ablation of tuberous sclerosis complex 2 in mice
Yutaka Shigeyama et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
Umut Ozcan et al.
MOLECULAR CELL (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
Latif Rachdi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity
Anil Kumar et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice
Carolina F. M. Z. Clemente et al.
CIRCULATION RESEARCH (2007)
Regulation of elongation phase of mRNA translation in diabetic nephropathy - Amelioration by rapamycin
Kavithalakshmi Sataranatarajan et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages
R. Andres Floto et al.
AUTOPHAGY (2007)
Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart
Saumya Sharma et al.
CARDIOVASCULAR RESEARCH (2007)
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
Frederic Tremblay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
4E-Binding protein 1:: A key molecular Funnel factor in human cancer with clinical implications
Gemma Armengol et al.
CANCER RESEARCH (2007)
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-P stimulation via the PI3K/Akt pathway
Sachiko Ito et al.
EXPERIMENTAL GERONTOLOGY (2007)
Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure
Ping Zhang et al.
CIRCULATION RESEARCH (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
High glucose, high insulin, and their combination rapidly induce laminin-β1 synthesis by regulation of mRNA translation in renal epithelial cells
Meenalakshmi M. Mariappan et al.
DIABETES (2007)
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
Olivier Le Bacquer et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
Amyloid-β peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway
Sachiko Ito et al.
NEUROSCIENCE RESEARCH (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
Maria A. Frias et al.
CURRENT BIOLOGY (2006)
Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling
Xiaonan Wang et al.
ENDOCRINOLOGY (2006)
Current development of mTOR inhibitors as anticancer agents
Sandrine Faivre et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Rapamycin delays but does not prevent recovery from acute renal failure: Role of acquired tubular resistance
Wilfred Lieberthal et al.
TRANSPLANTATION (2006)
Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats
Nuria Lloberas et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice
M Sakaguchi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Rapamycin alleviates toxicity of different aggregate-prone proteins
Z Berger et al.
HUMAN MOLECULAR GENETICS (2006)
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 30H-kinase
T Nobukuni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
LM Sparks et al.
DIABETES (2005)
Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy
JK Chen et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Rheb binds and regulates the mTOR kinase
X Long et al.
CURRENT BIOLOGY (2005)
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
L Khamzina et al.
ENDOCRINOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Dysregulation of the TSC-mTOR pathway in human disease
K Inoki et al.
NATURE GENETICS (2005)
eIF-4E expression and its role in malignancies and metastases
A De Benedetti et al.
ONCOGENE (2004)
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
DC Fingar et al.
ONCOGENE (2004)
mTOR-dependent activation of the transcription factor TIMA links rRNA synthesis to nutrient availability
C Mayer et al.
GENES & DEVELOPMENT (2004)
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
SH Um et al.
NATURE (2004)
Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy
CG Proud
CARDIOVASCULAR RESEARCH (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw et al.
CANCER CELL (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Regulation of peroxisome proliferator-activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis
JE Kim et al.
DIABETES (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
How long should insulin be used once a vial is started?
ME Molitch
DIABETES CARE (2004)
Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury
TF Fuller et al.
TRANSPLANTATION (2003)
Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
JR McMullen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee et al.
CURRENT BIOLOGY (2003)
Hexokinase II: The integration of energy metabolism and control of apoptosis
JG Pastorino et al.
CURRENT MEDICINAL CHEMISTRY (2003)
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes:: Potential role of PGC1 and NRF1
ME Patti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function
JE Wilson
JOURNAL OF EXPERIMENTAL BIOLOGY (2003)
Sirolimus prolongs recovery from delayed graft function after cadaveric renal transplantation
RA McTaggart et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2003)
Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure
J Megyesi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways - MEK-dependent activation of S6K2 in cardiomyocytes
LJ Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
M Pende et al.
NATURE (2000)
Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis
M Bärlund et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
RT Peterson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
