Journal
INFLAMMOPHARMACOLOGY
Volume 26, Issue 1, Pages 235-250Publisher
SPRINGER BASEL AG
DOI: 10.1007/s10787-017-0403-7
Keywords
Euphorbia tirucalli; Nociceptive pain; Anti-inflammatory; Anti-arthritic effect; Anti-asthmatic; Cytokine; Cyclooxygenase; Inducible nitric-oxide synthase
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Funding
- DST (SERB), Govt of India [SB/FT/LS-269/2012]
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The plant Euphorbia tirucalli Linn has been successfully used as a tribal folk medicine in India and Africa for the management of acute inflammatory, arthritic, nociceptive pain and asthmatic symptoms. The present study was conducted to assess the anti-inflammatory, analgesic, anti-asthmatic and anti-arthritic role of the total steroid and terpenoid rich fractions of the hydro-alcoholic extract of E. tirucalli root (STF-HAETR). STF-HAETR fraction demonstrated 71.25 +/- 2.5 and 74.25 +/- 5.1% protection against acetic acid-induced pain and central neuropathic pain at 75 and 100 mg/kg doses, respectively. It showed 96.97% protection against acute inflammation at 100 mg/kg with 1.6-fold better activity than the standard drug. The fraction exhibited such efficacy via inhibition of proinflammatory cytokines TNF-alpha, IFN-gamma, by 61.12 and 65.18%, respectively, at 100 mu g/mL. Inhibition of cyclooxygenase and Nitric oxide synthase in a dose-dependent manner affirms its analgesic and anti-inflammatory activity. The spectrophotometric analysis reveals that STF-HAETR induces ameliorative effect against heat-induced denaturation of Bovine serum albumin (BSA) and exhibits significant anti-proteinase activity. The plant fraction also demonstrated anti-asthmatic activity by displaying 62.45% protection against histamine induced bronchoconstriction or dyspnoea. Our findings suggest that STF-HAETR could be an effective safe therapeutic agent to treat nociceptive pain, acute inflammation, asthma, and arthritis which may authenticate its traditional use.
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