Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00761
Keywords
human gamma-delta T cell; cytotoxicity; cytokine; NK receptor; antigen presentation; cancer; infection; autoimmunity
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Funding
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- University Paris Descartes (Sorbonne Paris Cite)
- University Pierre et Marie Curie (Sorbonne University)
- Labex Immuno-Oncology [LAXE62_9UMS872]
- Institut National du Cancer (INCa-PLBio GDSTRESS)
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The unique features of gamma-delta (gamma delta) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of different pathologies. In this review, we focus on the main characteristics of human gamma delta T-cell subsets in diseases and the key mechanisms that could be explored to target these cells.
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