Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00021
Keywords
central fatigue; inflammation; immune system; multidimensional assessments; motivation; ventral striatum; anterior cingulate cortex; insula
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Funding
- Swedish Council for Working Life and Social Research
- Swedish Heart-Lung foundation
- Swedish Asthma and Allergy Association
- Swedish Brain Foundation
- Alexander von Humboldt foundation (Germany)
- Swedish Research Council
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Fatigue is a highly disabling symptom in various medical conditions. While inflammation has been suggested as a potential contributor to the development of fatigue, underlying mechanisms remain poorly understood. In this review, we propose that a better assessment of central fatigue, taking into account its multidimensional features, could help elucidate the role and mechanisms of inflammation in fatigue development. A description of the features of central fatigue is provided, and the current evidence describing the association between inflammation and fatigue in various medical conditions is reviewed. Additionally, the effect of inflammation on specific neuronal processes that may be involved in distinct fatigue dimensions is described. We suggest that the multidimensional aspects of fatigue should be assessed in future studies of inflammation-induced fatigue and that this would benefit the development of effective therapeutic interventions.
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