Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00405
Keywords
IL-6 classic signaling; IL-6 trans-signaling; podocyte; mesangial cells; endothelial cells; tubular epithelial cells; renal disease
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Funding
- National Natural Science Foundation of China [81522010, 81570671, 81470964, 31200872, 81570657, 81400720]
- Wuhan Science and Technology Bureau [2015060101010039]
- Ministry of Education of China [20130142110064]
- Academic Frontier Youth Team Program of Huazhong University of Science and Technology
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Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.
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