Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00508
Keywords
damage-associated molecular pattern; mitochondria; neuroinflammation; neurodegeneration; sterile inflammation
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Funding
- University of Kansas Alzheimer's Disease Center [P30 AG035982]
- Frank and Evangeline Thompson Alzheimer's Treatment Program fund
- Kansas IDeA Network for Biomedical Research Excellence (KINBRE) [P20GM103418]
- University of Kansas Medical Center Biomedical Research Training Program
- Mabel Woodyard Fellowship award
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Inflammation is increasingly implicated in neurodegenerative disease pathology. As no acquired pathogen appears to drive this inflammation, the question of what does remains. Recent advances indicate damage-associated molecular pattern ( DAMP) molecules, which are released by injured and dying cells, can cause specific inflammatory cascades. Inflammation, therefore, can be endogenously induced. Mitochondrial components induce inflammatory responses in several pathological conditions. Due to evidence such as this, a number of mitochondrial components, including mitochondrial DNA, have been labeled as DAMP molecules. In this review, we consider the contributions of mitochondrial-derived DAMPs to inflammation observed in neurodegenerative diseases.
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