Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01467
Keywords
T lymphocyte; CD28 costimulation; membrane rafts; immunological synapse; cytoskeleton
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Funding
- European Union's Seventh Framework Programme for research, technological development, and demonstration [602363]
- ERC [322823]
- European Research Council (ERC) [322823] Funding Source: European Research Council (ERC)
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Spatiotemporal compartmentalization of signaling pathways and second messengers is pivotal for cell biology and membrane rafts are, therefore, required for several lymphocyte functions. On the other hand, T cells have the specific necessity of tuning signaling amplification depending on the context in which the antigen is presented. In this review, we discuss of membrane rafts in the context of T cell signaling, focusing on CD28-mediated costimulation.
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