Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00933
Keywords
recent thymic; life span regulation; modeling and simulations; labeling; T cells subpopulations
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Funding
- Landsteiner Foundation for Blood Transfusion Research (LSBR) [0812]
- Netherlands Organization for Scientific Research (NWO) [917.96.350, 836.07.002]
- VIRGO consortium by Dutch Government [FES0908]
- Netherlands Genomics Initiative (NGI) [050-060-452]
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The peripheral naive T-cell pool is generally thought to consist of a subpopulation of recent thymic emigrants (RTEs) and a subpopulation of mature naive (MN) T cells with different dynamics. Thymus transplantation and adoptive transfer studies in mice have provided contradicting results, with some studies suggesting that RTEs are relatively short-lived cells, while another study suggested that RTEs have a survival advantage. We here estimate the death rates of RTE and MN T cells by performing both thymus transplantations and deuterium labeling experiments in mice of at least 12 weeks old, an age at which the size of the T-cell pool has stabilized. For CD4(+) T cells, we found the total loss rate from the RTE compartment (by death and maturation) to be fourfold faster than that of MN T cells. We estimate the death rate of CD4(+) RTE to be 0.046 per day, which is threefold faster than the total loss rate from the MN T-cell compartment. For CD8(+) T cells, we found no evidence for kinetic differences between RTE and MN T cells. Thus, our data support the notion that in young adult mice, CD4(+) RTE are relatively short-lived cells within the naive CD4(+) T-cell pool.
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