Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01636
Keywords
T-cells; lipid rafts; cholesterol; glycosphingolipids; fatty acids; nuclear receptors; autoimmunity; gender
Categories
Funding
- Lupus UK
- Rosetrees Trust [M409]
- British Heart Foundation [FS/13/59/30649]
- Academy of Medical Sciences
- University College London Hospital Clinical Research and Development Committee [F193]
- Rosetrees Trust [M409] Funding Source: researchfish
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It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation and function. Moreover, changes in PM lipid composition affect the biophysical properties of lipid rafts and have a role in defining functional T-cell phenotypes. Here, we review the role of transcriptional regulators of lipid metabolism including liver X receptors alpha/beta, peroxisome proliferator-activated receptor., estrogen receptors alpha/beta (ER alpha/beta), and sterol regulatory element-binding proteins in T-cells. These receptors lie at the interface between lipid metabolism and immune cell function and are endogenously activated by lipids and/or hormones. Importantly, they regulate cellular cholesterol, fatty acid, glycosphingolipid, and phospholipid levels but are also known to modulate a broad spectrum of immune responses. The current evidence supporting a role for lipid metabolism pathways in controlling immune cell activation by influencing PM lipid raft composition in health and disease, and the potential for targeting lipid biosynthesis pathways to control unwanted T-cell activation in autoimmunity is reviewed.
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