Journal
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
Volume 11, Issue 4, Pages 633-646Publisher
SPRINGER
DOI: 10.1007/s11705-017-1620-8
Keywords
nanomedicine; ferritin; drug delivery; bioassay; molecular imaging
Categories
Funding
- Major State Basic Research Development Program of China (973 Program) [2014CB744503, 2013CB733802]
- National Natural Science Foundation of China (NSFC) [81422023, 81371596, 51273165, U1505221]
- Fundamental Research Funds for the Central Universities [20720160065, 20720150141]
- Science Foundation of Fujian Province [2014Y2004]
- Program for New Century Excellent Talents in University, China [NCET-13-0502]
- Intramural Research Program (IRP), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- China Scholarship Council (CSC)
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Ferritin, a major iron storage protein with a hollow interior cavity, has been reported recently to play many important roles in biomedical and bioengineering applications. Owing to the unique architecture and surface properties, ferritin nanoparticles offer favorable characteristics and can be either genetically or chemically modified to impart functionalities to their surfaces, and therapeutics or probes can be encapsulated in their interiors by controlled and reversible assembly/disassembly. There has been an outburst of interest regarding the employment of functional ferritin nanoparticles in nanomedicine. This review will highlight the recent advances in ferritin nanoparticles for drug delivery, bioassay, and molecular imaging with a particular focus on their biomedical applications.
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