Journal
EXPERT REVIEW OF RESPIRATORY MEDICINE
Volume 11, Issue 5, Pages 395-402Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17476348.2017.1317597
Keywords
Severe asthma; difficult-to-treat asthma; asthma guidelines; phenotyping; management of asthma; eosinophilic asthma; exhaled nitric oxide
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Funding
- Asthma UK [MRC-AsthmaUKCentre, MRC-Asthma UK Centre] Funding Source: researchfish
- Medical Research Council [G1000758, G1000758B] Funding Source: researchfish
- Medical Research Council [G1000758] Funding Source: Medline
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Introduction: Severe therapy-resistant asthma is an area where there has been recent advances in understanding that is percolating into improvements in management.Areas covered: This review covers the recent definition and approach to the diagnosis of severe asthma and its differentiation from difficult-to-treat asthma. The recent advances in phenotyping severe asthma and in ensuing changes in management approaches together with the introduction of new therapies are covered from a review of the recent literature.Expert commentary: After ascertaining the diagnosis of severe asthma, patients need to be treated adequately with existing therapies. The management approach to severe asthma now comprises of a phenotyping step for the definition of either an allergic or eosinophilic severe asthma for which targeted therapies are currently available. This will lead to a precision medicine approach to the management of severe asthma.
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