Journal
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Volume 15, Issue 1, Pages 68-69Publisher
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
DOI: 10.9758/cpn.2017.15.1.68
Keywords
Disulfiram; Psychosis; Side effect
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Disulfiram is the commonly prescribed drug for the treatment of alcohol dependence. It's major metabolite (diethyldithiocarbamate) is an inhibitor of dopamine betahydroxylase, an enzyme that catalyzes the metabolism of dopamine to norepinephrine resulting in psychosis. We recommend that disulfiram should be used at the lowest effective dose, possibly 250 mg daily and caution should be taken while prescribing disulfiram for patients with personal and familial antecedents of psychosis.
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