Journal
NUCLEAR MEDICINE AND MOLECULAR IMAGING
Volume 50, Issue 4, Pages 358-361Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13139-015-0385-6
Keywords
FDG; FDG-PET/CT; Vaccine; Spleen; Lung cancer; Immunization
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A patient with newly diagnosed right lung cancer had transient F-18-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2-3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.
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