Flexible and Organic Neural Interfaces: A Review

Neural interfaces are a fundamental tool to interact with neurons and to study neural networks by transducing cellular signals into electronics signals and vice versa. State-of-the-art technologies allow both in vivo and in vitro recording of neural activity. However, they are mainly made of stiff inorganic materials that can limit the long-term stability of the implant due to infection and/or glial scars formation. In the last decade, organic electronics is digging its way in the field of bioelectronics and researchers started to develop neural interfaces based on organic semiconductors, creating more flexible and conformable neural interfaces that can be intrinsically biocompatible. In this manuscript, we are going to review the latest achievements in flexible and organic neural interfaces for the recording of neuronal activity.