Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 3, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2016.1143546
Keywords
Autophagy; cell size control; cancer; inflammation; myopathy; mevalonate pathway; proteostasis; RAB11; statins; senescence
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Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences cell size, growth, and proteostasis by regulating basal autophagic flux through geranylgeranylation of the small GTPase RAB11. The control of autophagy by the mevalonate/cholesterol pathway has potential implications for statin toxicity, inflammation, cancer, and neurodegenerative diseases.
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