Journal
ADVANCED SCIENCE
Volume 4, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/advs.201600407
Keywords
cancer targeting; conjugated polymers; fluorescence imaging; organic nanoparticles
Categories
Funding
- Singapore National Research Foundation [R279-000-443-281]
- National University of Singapore [R279-000-482133]
- Institute of Materials Research and Engineering of Singapore [IMRE/2-8P1103]
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Fluorescent and biocompatible organic nanoparticles have attracted great interest in cancer detection and imaging, but the nonspecific cellular uptake has limited the detection specificity and sensitivity. Herein, the authors report the ultrasmall conjugated polymer nanoparticles (CPNs) with bright far-red/near-infrared emission for targeted cancer imaging with high specificity. The sizes of the ultrasmall CPNs are around 6 nm (CPN6), while large CPNs show sizes around 30 nm (CPN30). Moreover, CPN6 exhibits largely improved fluorescence quantum yield (eta) of 41% than CPN30 (25%). Benefiting from the ultrasmall size, bare CPN6 shows largely suppressed nonspecific cellular uptake as compared to CPN30, while cyclic arginine-glycine-aspartic acid (cRGD) functionalized CPN6 (cRGD-CPN6) possesses excellent selectivity toward alpha(v)beta(3) integrin overexpressed MDA-MB-231 cells over other cells in cell mixtures. The faster body clearance of CPN6 over CPN30 indicates its greater potentials as a noninvasive nanoprobe for in vivo and practical applications.
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