Journal
ADVANCED SCIENCE
Volume 4, Issue 11, Pages -Publisher
WILEY
DOI: 10.1002/advs.201700325
Keywords
carbon nanodots; multicolor bioimaging; optogenetics; surface modification
Categories
Funding
- Bio & Medical Technology Development Program of the National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning, Korea [2012M3A9C6049791]
- Mid-career Researcher Program of the National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning, Korea [2015R1A2A1A15053779]
- Center for Advanced Soft-Electronics (Global Frontier Project) of the National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning, Korea [CASE-2015M3A6A5072945]
- Basic Science Research Program of the National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning, Korea [NRF-2016R1C1B1011830]
- Nano Material Technology Development Program of the National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning, Korea [2009-0082580]
- National Research Foundation of Korea [2016R1C1B1011830, 2012M3A9C6049791, 2015H1A2A1034059, 2015R1A2A1A15053779] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The development of intrinsically multicolor-emitting carbon nanodots (CNDs) has been one of the great challenges for their various fields of applications. Here, the controlled electronic structure engineering of CNDs is performed to emit two distinct colors via the facile surface modification with 4-octyloxyaniline. The so-called dual-color-emitting CNDs (DC-CNDs) can be stably encapsulated within poly(styrene-co-maleic anhydride) (PSMA). The prepared water-soluble DC-CNDs@PSMA can be successfully applied to in vitro and in vivo dual-color bioimaging and optogenetics. In vivo optical imaging can visualize the biodistribution of intravenously injected DC-CNDs@PSMA. In addition, the light-triggered activation of ion channel, channelrhodopsin-2, for optogenetic applications is demonstrated. As a new type of fluorophore, DC-CNDs offer a big insight into the design of charge-transfer complexes for various optical and biomedical applications.
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