Journal
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
Volume 73, Issue -, Pages 373-378Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S2059798317002996
Keywords
macromolecular crystallography; serial synchrotron crystallography; fixed target; room-temperature crystallography; crystallography on a chip; low dose
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Max Planck Society
- Canadian Institute for Advanced Research
- Canada Excellence Research Chairs program
- People Programme (Marie Curie Actions) of the European Union under REA grant [623994]
- Deutsche Forschungsgemeinschaft
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The development of serial crystallography has been driven by the sample requirements imposed by X-ray free-electron lasers. Serial techniques are now being exploited at synchrotrons. Using a fixed-target approach to high-throughput serial sampling, it is demonstrated that high-quality data can be collected from myoglobin crystals, allowing room-temperature, low-dose structure determination. The combination of fixed-target arrays and a fast, accurate translation system allows high-throughput serial data collection at high hit rates and with low sample consumption.
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