Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 3, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2016.1187322
Keywords
AMPK; BRCA1; energy stress response; lncRNA; NBR2; tumor suppression
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Funding
- NCI NIH HHS [R01 CA190370, R01 CA181196] Funding Source: Medline
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NBR2 (neighbor of BRCA1 gene 2) is a non-protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate-activated protein kinase (AMPK) activation.
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