Journal
ACS INFECTIOUS DISEASES
Volume 4, Issue 3, Pages 315-324Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.7b00183
Keywords
S. agalactiae; GBS; S. aureus; A. baumannii; antimicrobial; antibiofilm
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Funding
- Vanderbilt University
- Department of Pediatrics at Vanderbilt University Medical Center
- Institute of Chemical Biology
- Department of Veterans Affairs [CDA-2 1IK2BX001701]
- Amgen Foundation
- Vanderbilt Pre3 Initiative (Preventing adverse Pregnancy outcomes & Prematurity, a Transinstitutional Program of Vanderbilt University)
- Mitchum E. Warren, Jr. Graduate Research Fellowship
- Vanderbilt Chemical Biology Interface (CBI) training program [T32 GM065086]
- Vanderbilt Pre3 Initiative
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In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.
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