Journal
ACS INFECTIOUS DISEASES
Volume 4, Issue 2, Pages 118-122Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.7b00178
Keywords
oxidative coupling; antibiotic; oral microbiome; natural product
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Funding
- NIH [GM112684, DE025837, T32 GM071339]
- NSF [CHE1464778, CHE1755698, 1S10RR023444, 1S10RR022442, CHE 0840438, CHE-0848460, 1S10OD011980]
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The oral microbiome is a complex ecological niche where both commensal and pathogenic bacteria coexist. Previous reports have cited that the plant isolate honokiol is a potent inhibitor of S. mutans biofilms. Herein we report a cross-coupling method that provides access to a concise library of honokiol-inspired analogs. Through this work we determined that the inhibitory activity of honokiol is highly dependent on the growth conditions. Further, we identify a series of analogs that display significant potency against oral bacteria leading to the discovery of a potent antimicrobial.
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