Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 12, Pages 3098-3122Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00655
Keywords
Biomaterials; peripheral nerve injury; regeneration; growth factors; cell therapy; gene therapy
Categories
Funding
- European Community's Seventh Framework Programme [278612]
- ERDF/POCTEP [0687_NOVOMAR_1_P]
- European Union Seventh Framework Programme [REGPOT-CT2012-316331-POLARIS]
- ComplexiTE [ERC-2012-ADG_20120216-321266]
- Portuguese Foundation for Science and Technology (FCT) [IF/00115/2015, IF/01285/2015, IF/00423/2012]
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Damage to peripheral nerves is a widely extended health problem, causing important socioeconomic costs worldwide. Indeed, peripheral nerve injuries (PNI) have been concerning the medical community for many decades. Nevertheless, despite the increase in knowledge in the injury physiopathology and the great research efforts being undertaken, the current standard grafting strategies used to repair PNI are not as efficient as desired. Although alternative engineered nerve grafts are already commercialized, their clinical performance is suboptimal. In this review, a general description of the circumstances and repercussions surrounding the PNI pathological state are presented, together with the treatment limitations and current challenges when addressing both short- and long-gap defects. In addition, potential therapeutic molecules are considered, while innovative regenerative strategies have been identified. Finally, the most relevant advances on the use of a wide range of biomaterials for the development of novel medical devices are also overviewed in depth, considering strategies making use of either empty or filled nerve conduits for guided tissue regeneration.
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