Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 11, Pages 2798-2805Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00772
Keywords
multiscale biomechanics; skeletal muscle; hyperelastic warping; deformable image registration; deformation; strain
Categories
Funding
- AHA [14SDG18220010]
- NIH [R01 AR063712, R21 AR064178, R21 AR066230]
- NSF [CAREER 1349735]
Ask authors/readers for more resources
Biological tissues have a complex hierarchical architecture that spans organ to subcellular scales and comprises interconnected biophysical and biochemical machinery. Mechanotransduction, gene regulation, gene protection, and structure function relationships in tissues depend on how force and strain are modulated from macro to microscales, and vice versa. Traditionally, computational and experimental techniques have been used in common model systems (e.g., embryos), and simple strain measures were applied. However, the hierarchical transfer of mechanical parameters like strain in mammalian systems is largely unexplored in vivo. Here, we experimentally probed complex strain transfer processes in mammalian skeletal muscle tissue over multiple biological scales using complementary in vivo ultrasound and optical imaging approaches. An iterative hyperelastic warping technique quantified the spatially dependent strain distributions in tissue, matrix, and subcellular (nuclear) structures, and revealed a surprising increase in strain magnitude and heterogeneity in active muscle as the spatial scale also increased. The multiscale strain heterogeneity indicates tight regulation of mechanical signals to the nuclei of individual cells in active muscle and an emergent behavior appearing at larger (e.g., tissue) scales characterized by dramatically increased strain complexity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available