Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 8, Pages 1836-1844Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00110
Keywords
microwave; microwave induced photodynamic therapy (MIPDT); graphitic-C3N4 quantum dots; tumor; singlet oxygen
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Funding
- National Natural Science Foundation of China [81501859, 21620102004, 51472013]
- Natural Science Foundation of Guangdong Province, China [2015A030312004]
- Science and Technology Planning Project of Guangdong Province [201604020110]
- National Key Research and Development Program of China [2016YFB0700800]
- U.S. Army Medical Research Acquisition Activity (USAMRAA) [W81XWH-10-1-0279, W81XWH-10-1-0234]
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Here, we report our new observations on graphitic-phase carbon nitride (g-C3N4) quantum dots (QDs) as agents for microwave induced photodynamic therapy (MIPDT). For the first time, we observed that singlet oxygen is produced in g-C3N4 QDs by microwave irradiation, which can be used for tumor destruction. The results of live/dead staining and flow cytometry show that g-C3N4 QDs based MIPDT can effectively kill cancer cells and promote tumor cell death. In addition, the cell viability and hemolysis tests in vitro indicate that g-C3N4 QDs have very low cell toxicity and possess excellent biocompatibility in the physiological environments. All these indicate that g-C3N4 QDs are promising for MIPDT, a new potential modality for cancer treatment.
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