Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 9, Pages 2136-2143Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00255
Keywords
liposome; drug delivery; nitric oxide; controlled-release; serum; blood
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Funding
- National Institutes of Health [DE025207]
- National Science Foundation of the National Nanotechnology Coordinated Infrastructure (NNCI) [ECCS-1542015]
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We report the ability to readily tune NO release from N-diazeniumdiolate-encapsulated liposomal structures by altering the NO donor molecule structure and/or phospholipid composition (independently or in combination). While encapsulating more stable NO donors expectedly enhanced the NO release (up to 48 h) from the liposomes, the phospholipid headgroup surface area proved equally useful in controlling NO-release kinetics by influencing the proton uptake and concomitant N-diazeniumdiolate NO donor breakdown (to NO). The potential therapeutic utility of the NO-releasing liposomes was further assessed in biological/proteinaceous fluids. The NO-release kinetics were similar in buffer and serum.
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