Journal
STEM CELL REPORTS
Volume 9, Issue 5, Pages 1463-1476Publisher
CELL PRESS
DOI: 10.1016/j.stemcr.2017.09.023
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Funding
- NIGMS [GM109089]
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Default differentiation of human pluripotent stem cells has been promoted as a model of cortical development. In this study, a developmental transcriptome analysis of default-differentiated hPSNs revealed a gene expression program resembling in vivo CGE/LGE subpallial domains and GABAergic signaling. A combination of bioinformatic, functional, and immunocytochemical analysis further revealed that hPSNs consist of both cortical glutamatergic and CGE-like GABAergic neurons. This study provides a comprehensive characterization of the heterogeneous group of neurons produced by default differentiation and insight into future directed differentiation strategies.
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