Journal
INTRACTABLE & RARE DISEASES RESEARCH
Volume 5, Issue 4, Pages 284-289Publisher
INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
DOI: 10.5582/irdr.2016.01067
Keywords
Acetazolamide; osteopetrosis; carbonic anhydrase inhibitor; craniometaphyseal dysplasia; osteochondrodysplasia; sclerosing bone dysplasia
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Sclerosing bone dysplasias are a series of clinically and genetically heterogeneous diseases characterized by functional failure of the osteoclasts in bone resorption, leading to an excessive amount of bone mineral density (BMD) which could have serious clinical consequences. We treated three children affected with seriously high levels of BMD with acetazolamide, with the intention of inducing metabolic acidosis, thus increasing bone resorption and reducing BMD. All our patients tolerated and followed the treatment well and the clinical response was satisfactory in all cases.
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