Journal
NEUROIMAGE-CLINICAL
Volume 16, Issue -, Pages 545-556Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2017.09.006
Keywords
Bipolar disorder; Gaze processing; Face recognition; Memory; ERP; EEG source imaging
Categories
Funding
- Swiss National Center of Competence in Research
- Swiss National Science Foundation [51NF40-158776, 320030_159705, 32003B_156914]
- Center for Biomedical Imaging (CIBM) of Geneva
- Center for Biomedical Imaging (CIBM) of Lausanne
Ask authors/readers for more resources
Gaze conveys emotional information, and humans present sensitivity to its direction from the earliest days of life. Bipolar disorder is a disease characterized by fluctuating states of emotional and cognitive dysregulation. To explore the role of attentional control on face processing in bipolar patients (BP) we used gaze direction as an emotion modulation parameter in a two-back Working Memory (WM) task while high-density EEG data were acquired. Since gaze direction influences emotional attributions to faces with neutral expressions as well, we presented neutral faces with direct and averted gaze. Nineteen euthymic BP and a sample of age-and gender-matched controls were examined. In BP we observed diminished P200 and augmented P300 evoked responses, differentially modulated by non-repeated or repeated faces, as well as by gaze direction. BP showed a reduced P200 amplitude, significantly stronger for faces with direct gaze than averted gaze. Source localization of P200 indicated decreased activity in sensory-motor regions and frontal areas suggestive of abnormal affective processing of neutral faces. The present study provides neurophysiological evidence for abnormal gaze processing in BP and suggests dysfunctional processing of direct eye contact as a prominent characteristic of bipolar disorder.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available