TDCS modulates cortical excitability in patients with disorders of consciousness

Transcranial direct current stimulation (tDCS) 1 has been reported to be a promising technique for consciousness improvement for patientswith disorders of consciousness (DOC). 2 However, there has been no direct electrophysiological evidence to demonstrate the efficacy of tDCS on patients with DOC. Therefore, we aimtomeasure the cortical excitability changes induced by tDCS in patients with DOC, to find electrophysiological evidence supporting the therapeutic efficacy of tDCS on patients with DOC. In this study, we enrolled sixteen patientswith DOC, including nine vegetative state (VS) 3 and seven minimally conscious state (MCS) 4 (six females and tenmales). TMS-EEG was applied to assess cortical excitability changes after twentyminutes of anodal tDCS of the left dorsolateral prefrontal cortex. Global cerebral excitability were calculated to quantify cortical excitability in the temporal domain: four time intervals (0-100, 100-200, 200-300, 300-400ms). Then local cerebral excitability in the significantly altered time windows were investigated (frontal, left/right hemispheres, central, and posterior). Compared to baseline and sham stimulation, we found that global cerebral excitability increased in early timewindows (0-100 and 100-200ms) for patientswithMCS; for the patientswith VS, global cerebral excitability increased in the 0-100ms interval but decreased in the 300-400 ms interval. The local cerebral excitability was significantly different between MCS and VS. The results indicated that tDCS can effectively modulate the cortical excitability of patients with DOC; and the changes in excitability in temporal and spatial domains are different between patients with MCS and those with VS. (C) 2017 The Authors. Published by Elsevier Inc.