Journal
NEUROIMAGE-CLINICAL
Volume 15, Issue -, Pages 581-586Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2017.06.009
Keywords
APPswe/PS1dE9 mice; Neuronal loss; A beta-plaques; NAA/Cr ratio; Brain atrophy
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Funding
- German Research Foundation (DFG, Bonn-Bad Godesberg, Germany) [KU 3280/1-1]
- Marie-Curie Innovative Training Network BBDiag (EU-Horizon2020) [721281]
- Medical Faculty of the Rostock University Medical Center
- Marie Curie Actions (MSCA) [721281] Funding Source: Marie Curie Actions (MSCA)
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Transgenic animal models of A beta pathology provide mechanistic insight into some aspects of Alzheimer disease (AD) pathology related to A beta accumulation. Quantitative neuroimaging is a possible aid to improve translation of mechanistic findings in transgenic models to human end phenotypes of brain morphology or function. Therefore, we combined MRI-based morphometry, MRS-based NAA-assessment and quantitative histology of neurons and amyloid plaque load in the APPswe/PS1dE9 mouse model to determine the interrelationship between morphological changes, changes in neuron numbers and amyloid plaque load with reductions of NAA levels as marker of neuronal functional viability. The APPswe/PS1dE9 mouse showed an increase of A beta plaques, loss of neurons and an impairment of NAA/Cr ratio, which however was not accompanied with brain atrophy. As brain atrophy is one main characteristic in human AD, conclusions from murine to human AD pathology should be drawn with caution.
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