Journal
NANOTECHNOLOGY REVIEWS
Volume 6, Issue 5, Pages 435-448Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/ntrev-2017-0115
Keywords
3D microcarriers; direct injection; hydrogel; stem cell therapy
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Funding
- National Natural Science Foundation of P.R. China [81170492, 81370673]
- National High Technology Research and Development Program 863 of P.R. China [2012AA022703]
- National Key Basic Research Program 973 of P.R. China [2010CB732404]
- Key Medical Projects of Jiangsu Province [BL2014078]
- Key Discipline of Jiangsu Province
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Compared with systematic administration such as peripheral intravenous infusion, stem cell therapy by direct injection is theoretically more effective, but some technical barriers such as low stem cell retention rate and low engraftment rate still need to be overcome before its application in humans. Stem cell therapy supported by hydrogel carriers has been increasingly studied in recent years. These hydrogels with properties similar to natural tissues are able to fabricate various forms of carriers, which include in situ forming hydrogels, ex situ forming hydrogels, surface immobilization carriers, microencapsules, and microgels. Some of them are 3D carriers and promise to overcome the technical barriers of stem cell therapy by direct injection. They have different characteristics, application, and prospect in the application of stem cell therapy by direct injection, which is summarized by this review.
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