4.7 Article

Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials

Journal

NANOMATERIALS
Volume 7, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/nano7020043

Keywords

gold nanoparticles; lipoic acid; thioctic acid; antimicrobial; cytotoxicity; cellular cycle

Funding

  1. Romanian National Authority for Scientific Research, CNCS - UEFISCDI
  2. [PN16-480102]

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Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4 0 -aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4 0 -aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activity, as well as for their influence on mammalian cell viability and cellular cycle. In all cases a decreased antimicrobial activity of the obtained bioactive nanoparticles was observed as compared with the organic compounds, proving that a possible inactivation of the bioactive groups could occur during functionalization. However, both the gold nanoparticles as well as the functionalized bioactive nanosystems proved to be biocompatible at concentrations lower than 50 mu g/mL, as revealed by the cellular viability and cell cycle assay, demonstrating their potential for the development of novel antimicrobial agents.

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